Publikationen

Szumska, J., Batool, Z., Al-Hashimi, A., Venugopalan, V., Skripnik, V., Schaschke, N., Bogyo, M., Brix, K. (2019). Treatment of Rat Thyrocytes in vitro with Cathepsin B and L Inhibitors Results in Disruption of Primary Cilia Leading to Redistribution of the Trace Amine Associated Receptor 1 to the Endoplasmic Reticulum. https://doi.org/10.1016/j.biochi.2019.07.010.

Sendler, M., Maertin, S., John, D., Persike, M., Weiss, F. U., Krüger, B., Wartmann, T., Wagh, P., Halangk, W., Schaschke, N., Mayerle, J., and Lerch, M. M. (2016). Cathepsin B Activity Initiates Apoptosis via Digestive Protease Activation in Pancreatic Acinar Cells and Experimental Pancreatitis. J. Biol. Chem., 291, 14717-1473.

Tamhane, T., Arampatzidou, M., Gerganova, V., Tacke, M., Illukkumbura, R., Dauth, S., Schaschke, N., Peters, C., Reinheckel, T., and Brix, K. (2014). The Activity and Localization Patterns of Cathepsins B and X in Cells of the Mouse Gastrointestinal Tract Differ Along its Length. Biol. Chem., 395, 1201-1219.

Mikhaylov, G., Klimpel, D., Schaschke, N., Mikac, U., Vizovisek, M., Fonovic, M., Turk, V., Turk, B., and Vasiljeva, O. (2014). Selective Targeting of Tumor and Stromal Cells by a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor. Angew. Chem., 126, 10241-10245.

Mikhaylov, G., Klimpel, D., Schaschke, N., Mikac, U., Vizovisek, M., Fonovic, M., Turk, V., Turk, B., and Vasiljeva, O. (2014). Selective Targeting of Tumor and Stromal Cells by a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor. Angew. Chem. Int. Ed., 53, 10077-10081.

Radzey, H., Rethmeier, M., Klimpel, D., Grundhuber, M., Sommerhoff, C. P., and Schaschke, N. (2013). E-64c-Hydrazide: A Lead Structure for the Development of Irreversible Cathepsin C Inhibitors. ChemMedChem, 8, 1314-1321.

Diederich, S., Sauerhering, L., Weis, M., Altmeppen, H., Schaschke, N., Reinheckel, T., Erbar, S., and Maisner, A. (2012). Activation of the Nipah Virus Fusion Protein in MDCK Cells is Mediated by Cathepsin B within the Endosomal-Recycling Compartment. J. Virol., 86, 3736-3745.

Tabares, P., Degel, B., Schaschke, N., Hentschel, U., and Schirmeister, T. (2012). Identification of the Protease Inhibitor Miraziridine A in the Red Sea Sponge Theonella swinhoei. Pharmacognosy Research, 4, 63-66.

Kalińska, M., Kantyka, T., Greenbaum, D. C., Larsen, K. S., Władyka, B., Jabaiah, A., Bogyo, M., Daugherty, P. S., Wysocka, M., Jaros, M., Lesner, A., Rolka, K., Schaschke, N., Stennicke, H., Dubin, A., Potempa, J., and Dubin, G. (2012). Substrate Specificity of Staphylococcus aureus Cysteine Proteases – Staphopains A, B and C. Biochimie, 94, 318-327.

Dennis, J., Sommerhoff, C. P., and Schaschke, N. (2011). The Arginine Mimicking b-Amino Acid b3hPhe(3-H2N-CH2)-OH as S1 Ligand in Cyclo-theonamide-based b-Tryptase Inhibitors. Bioorg. Med. Chem., 19, 7236-7243.

Schurigt, U., Schad,C., Glowa, C., Baum, U., Thomale, K., Schnitzer, J. K., Schultheis, M., Schaschke, N., Schirmeister, T., and Moll, H. (2010). Aziridine-2,3-Dicarboxylate-Based Cysteine Cathepsin Inhibitors Induce Cell Death in Leishmania major Associated with Accumulation of Debris in Autophagy-related Lysosome-like Vacuoles. Antimicrob. Agents Chemother., 54, 5028-5041.

Schaschke, N., and Sommerhoff, C. P. (2010). Upgrading a natural product: Inhibition of Human b-Tryptase by Cyclotheonamide Analogues. ChemMedChem, 5, 367-370.

Schaschke, N., Assfalg-Machleidt, I., and Machleidt, W. (2008). Inhibition of Cathepsin L by Epoxysuccinly Peptides Addressing Simultaneously Active-site and Remote-site Regions. ChemBioChem, 9, 1721-1724.

Pfizer, J., Assfalg-Machleidt, I., Machleidt, W., and Schaschke, N. (2008). Inhibition of Human µ-Calpain by Conformationally Constrained Calpastatin Peptides. Biol. Chem., 389, 83-90.

Büth, H., Buttigieg, P.L., Ostafe, R., Rehders, M., Dannenmann, S.R., Schaschke, N., Stark, H.-J., Boukamp P., and Brix, K. (2007). Cathepsin B is Essential for Regeneration of Scratch-wounded Normal Human Epidermal Keratinocytes. Eur. J. Cell Biol., 86, 747-761.

Pfizer, J.M., Assfalg-Machleidt, I., Machleidt, W., Moroder L., and Schaschke, N. (2007). Primed-site Probing of Papain-like Cysteine Proteases. International Journal of Peptide Research and Therapeutics, 13, 93-104.

Schaschke, N., Gabrijelcic-Geiger, D., Dominik, A., and Sommerhoff, C. P. (2005). Affinity Chromatography of Tryptases: Design, Synthesis and Characterization of a Novel Matrix-bound Bivalent Inhibitor. ChemBioChem, 6, 95-103.

Büth, H., Wolters, B., Hartwig, B., Meier-Bornheim, R., Veith, H., Hansen, M., Sommerhoff, C. P., Schaschke, N., Machleidt, W., Fusenig, N. E., Boukamp, P., and Brix, K. (2004). HaCaT Keratinocytes Secrete Lysosomal Cysteine Proteinases During Migration. Eur. J. Cell Biol., 83, 781-795.

Giragossian, C., Schaschke, N., Moroder, L., and Mierke, D. F. (2004). Conformational and Molecular Modeling Studies of b-Cyclodextrin-Heptagastrin and Third Extracellular Loop of the Cholecystokinin 2 Receptor. Biochemistry 43, 2724-2731.

Štern, I., Schaschke, N., Moroder, L., and Turk, D. (2004). Crystal Structure of
NS-134 in Complex with Bovine Cathepsin B: A Two-Headed Epoxysuccinyl Inhibitor Extends Along the Entire Active-Site Cleft. Biochem. J., 381, 511-517.

Schaschke, N. (2004). Miraziridine A: Natures Blueprint Towards Protease Class-spanning Inhibitors. Bioorg. Med. Chem. Lett., 14, 855-857.

Gil-Parado, S., Assfalg-Machleidt, I., Fiorino, F., Deluca, D., Pfeiler, D., Schaschke, N., Moroder, L., and Machleidt, W. (2003). Calpastatin Exon 1B-Derived Peptide, a Selective Inhibitor of Calpain: Enhancing Cell Permeability by Conjugation with Penetratin. Biol. Chem., 384, 395-402.

Schaschke, N., Dominik, A., Matschiner, G., and Sommerhoff, C. P. (2002). Bivalent Inhibition of b-Tryptase: Distance Scan of Neighboring Subunits by Dibasic Inhibitors. Bioorg. Med. Chem. Lett. 12, 985-988.

Balaji, K. N., Schaschke, N., Machleidt, W., Catalfamo, M., and Henkart P. A. (2002). Surface Cathepsin B Protects Cytotoxic Lymphocytes from Self-Destruction after Degranulation. J. Exp. Med. 196, 493-503.

Schaschke, N., Deluca, D., Assfalg-Machleidt, I., Höhneke, C., Sommerhoff, C. P., and Machleidt, W. (2002). Epoxysuccinyl Peptide-derived Cathepsin B Inhibitors: Modulating Membrane Permeability by Conjugation with the C-terminal Heptapeptide Segment of Penetratin. Biol. Chem. 338, 849-852.

Schaschke, N., Matschiner, G., Zettl, F., Marquardt, U., Bergner, A., Bode, W., Sommerhoff, C. P., and Moroder, L. (2001). Bivalent Inhibition of Human b-Tryptase. Chem. Biol. 8, 313-327.

Schaschke, N., Assfalg-Machleidt, I., Laßleben, T., Sommerhoff, C. P., Moroder, L., and Machleidt, W. (2000). Epoxysuccinyl Peptide-Derived Affinity Labels for Cathepsin B. FEBS Lett. 482, 91-96.

Schaschke, N., Assfalg-Machleidt, I., Machleidt, W., Laßleben, T., Sommerhoff, C. P., and Moroder, L. (2000). b-Cyclodextrin/Epoxysuccinyl Peptide Conjugates: A New Drug Targeting System for Tumor Cells. Bioorg. Med. Chem. Lett. 10, 677-680.

Schaschke, N., Assfalg-Machleidt, I., Machleidt, W., and Moroder, L. (1998). Substrate/Propeptide Derived Endo-Epoxysuccinyl Peptides as Highly Potent and Selective Cathepsin B Inhibitors. FEBS Lett. 421, 80-82.

Schaschke, N., Fiori, S., Weyher, E., Escrieut, C., Fourmy, D., Müller, G., and Moroder, L. (1998). Cyclodextrin as Carrier of Peptide Hormones. Conformational and Biological Properties of b-Cyclodextrin/Gastrin Constructs. J. Am. Chem. Soc. 120, 7030-7038.

Schaschke, N., Musiol, H.-J., Assfalg-Machleidt, I., Machleidt, W., and Moroder, L. (1997). Oligopresentation of Protease Inhibitors with b-Cyclodextrin as Template. Bioorg. Med. Chem. Lett. 7, 2507-2512.

Schaschke, N., Assfalg-Machleidt, I., Machleidt, W., Turk, D., and Moroder, L. (1997). E-64 and Related Analogs as Inhibitors of Cathepsin B. On the Role of the Absolute Configuration of the Trans-Epoxysuccinyl Group. Bioorg. Med. Chem. 5, 1789-1797.

Schaschke, N., Musiol, H.-J., Assfalg-Machleidt, I., Machleidt, W., Rudolph-Böhner, S., and Moroder, L. (1996). Cyclodextrins as Templates for the Presentation of Protease Inhibitors. FEBS Lett. 391, 297-301.

Sommerhoff, C. P., Schaschke N. (2007). Mast Cell Tryptase b as Target in Allergic Inflammation: An Evolving Story. Curr. Pharm. Design, 13, 313-332.

Schaschke N. (2007). (2S,3S)-Oxirane-2,3-dicarboxylic acid: A Privileged Platform for Probing Human Cysteine Cathepsins. J. Biotechnol., 129, 308-315.

Schaschke, N., Alefelder, S., Musiol, H.-J., and Moroder L. (2002). Misellaneous Coupling Reagents, In: Houben-Weyl, Vol. E22a, A. Felix, L. Moroder and M. Goodman, eds. (Stuttgart, New York: Thieme), pp. 581-588.

Moroder, L., Musiol, H.-J., Schaschke, N., Chen, L., Hargittai, B., and Barany G. (2002). Protection of the Thiol Group. In: Houben-Weyl, Vol. E22a, A. Felix, L. Moroder and M. Goodman, eds. (Stuttgart, New York: Thieme), pp. 384-423.

Andexer, J. N., Beifuss, U., Beuerle, F., Brasholz, M., Breinbauer, R., Ernst, M., Gulder, T. A. M., Kath‐Schorr, S., Kordes, M., Lehmann, M., Lindel, T., Lüdeke, S., Luy, B., Mantel, M., Mück‐Lichtenfeld, C., Muhle‐Goll, C., Narine, A., Niemeyer, J., Pfau, R., Pietruszka, J., Schaschke, N., Senge, M. O., Straub, B. F., Werner, T., Werz, D. B., and Winter. C. (2019). Organische Chemie. Nachr. Chem., 67(3), 46-78.

Straub, B., Andexer, J. N., Arenz, C., Beifuss, U., Beuerle, F., Brasholz, M., Breinbauer, R., Ditrich, K., Ernst, M., Gulder, T. A. M., Kordes, M., Krueger, A., Lehmann, M., Lindel, T., Lüdeke, S., Luy, B., Meier, M. A. R., Mück‐Lichtenfeld, C., Muhle‐Goll, C., Narine, A., Paradies, J., Pfau, R., Pietruszka, J., Schaschke, N., Senge, M. O., Werner, T., Werz, D. B., Winter, C., and Worgull, D. (2018). Trendbericht Organische Chemie 2017. Nachr. Chem., 66, 249-280.

Straub, B. F., Andexer, J., Arenz, C., Beifuss, U., Beuerle, F., Brasholz, M., Breinbauer, R., Ditrich, K., Gulder, T. A. M., Hüttel, W., Kordes, M., Krueger, A., Lehmann, M., Lindel, T., Luy, B., Meier, M. A. R., Mück-Lichtenfeld, C., Muhle-Goll, C., Müller, T. J. J., Narine, A., Paradies, J., Pfau, R., Pietruszka, J., Schaschke, N., Senge, M. O., Werner, T., Werz, D. B., Winter, C. A., and Worgull, D. (2017). Organische Chemie 2016. Nachr. Chem., 65, 266-304.

Itzen, A., Schaschke, N., Beifuss, U., Lehmann, M., Krueger, A., Beuerle, F., Senge, M. O., Breinbauer, R., Mück-Lichtenfeld, C., Müller, T. J. J., Denißen, M., Lindel, T., Pietruszka, J., Worgull, D., Gulder, T., Paradies, J., Muñiz, K., Bach, T., Ditrich, K., Winter, C., Kordes, M., von Deyn, W., Pfau, R., Muhle-Goll, C., Luy, B., Werz, D. B., Arenz, C., Hüttel, W. Andexer, J. N., and Straub B. F. (2016), Organische Chemie. Nachr. Chem., 64, 255-294.

Schaschke, N., Sommerhoff, C. P. (2014). b-Tryptase-Inhibitoren als Wirkstoffe gegen allergisches Asthma. BIOspektrum, 20, 517-519.

Schaschke, N. (2009). Notizen in der Rubrik Chemie. Nachrichten, 57, 6-8, 114-116, 216-218, 372-374, 494-497, 622-624, 736-738, 850-854.

Schaschke, N. (2008). Notizen in der Rubrik Biowissenschaften. Nachrichten, 56, 8, 116, 234, 406, 511, 631, 730, 868, 994, 1108, 1224.