Prof. Dr. Christian Neusüß

Room

116

Telephone

+49 7361 576-2399

Email Address

Research
Resumé
Publications

The academic study and workplace training; academic knowledge and practical experience; theory and practice of instrumental analytical chemistry and bioanalytics are the main contents of my teaching. These contents are special fields of the masters/master's programme "Analytical and Bioanalytical Chemistry". In addition to advanced courses / specialties in the fundamentals of inorganic, council and physical chemistry, the course focuses on topics in analytics, spectroscopy and biochemistry. As Dean of Studies, Studies Dean of this exciting course, I welcome your interest and will be happy to answer any questions you may have.

In the field (of) research, I am mainly concerned with the coupling of modern separation techniques (CE, LC) with mass spectrometry. As a comparatively rarely practiced School of Engineering, we have built up a great deal of expertise in CE/MS. In addition to fundamental work, this involves a wide range of applications in pharmaceutical analysis, environmental analysis and structure determination. Together with my doctoral candidates, doctoral students and students writing their Masters (UK)/master's (US) thesis or project, we have a lot of fun working in a state-of-the-art laboratory / lab.

Research Projects

Characterization of intact glycoproteins (e.g. EPO) using CE-MS
Method development for the characterization of glycans, based on CE-LIF, CE-MS and LC-MS

Collaboration, cooperation with several (bio)pharmaceutical companies.

Project GEMSE 01.06.2010 - 31.05.201375 KBPDF

The project with the title "Capillary electrophoresis/mass spectrometry - new approach for coupling two important techniques for protein characterization" is funded and supported by the BMBF through the 2010 round of funding for the qualification of young engineers.

Sub-project of MIME 01.11.2011 - 31.10.201469 KBPDF

The sub-project runs under the joint project Multimodal Pattern Recognition System for the Protection of the Population against Organized Drug Crime and for Combating International Drug Trafficking as part of the BMBF's "Securing Commodity Chains" announcement under the Federal Government's "Research for Civil Security" program.

Equipment

Various LC, CE and GC instruments can be coupled with MS, UV, fluorescence, LIF, conductivity detection

Equipment	manufacturer	Variant/Detection
Liquid chromatography*
LC Ultimate 3000	Dionex	LC or capLC
HPLC 1050	Hewlett Packard / Agilen	UV, fluorescence, conductivity detection
HPLC 1100	Agilent	UV, DAD, conductivity detection
HPLC LC-10A VP	Shimadzu	DAD
LC	LDC	Fluorescence (Shimadzu RF-551)

Gas chromatography
GC 5890 Series II Plus	Hewlett Packard / Agilent
GC 5710A	Hewlett Packard / Agilent
GC MCS 5890 Series II	Gerstel
GC-MSD 5890 Series II	Hewlett Packard / Agilent	Quadrupole MS, optional with headspace

Capillary electrophoresis*
CE 7100	Agilent	Optional flexible UV/VIS absorption or LIF at 488nm or 266nm (J+M Analytics)
P/ACE MDQ CE	Beckman Coulter	Optional flexible UV/VIS absorption or LIF at 488nm or 266nm (J+M analytics)
P/ACE System 5500	Beckman Coulter	Optional flexible UV/VIS absorption or LIF at 488nm or 266nm (J+M Analytics)
P/ACE System 5500	Beckman Coulter	Optional flexible UV/VIS absorption or LIF at 488nm or 266nm (J+M Analytics)

Mass spectrometer
Ion trap Esquire 6000	Bruker Daltonics
MicroTOFq-MS	Bruker Daltonics

UV/VIS spectroscopy
UV/VIS spectrometer LKB Ultrospec Plus	Pharmacia

Raman spectroscopy
Raman spectrometer (785nm)	Polytec / J+M Analytics

1989 - today Appointment funding for professors; appointment funds

Nobuaki Takemori, Philipp T. Kaulich, Jan Hahn, Hartmut Schlüter, Naoyuki Sugiyama, Kazuya Tsumagari, Yasushi Ishihama, Sabine Fuchs, Mio Iwasaki, Franz‐Josef Müller, Christian Neusüß, Kyowon Jeong, Oliver Kohlbacher, Yoshihiro Shimizu, Yoichi Otsuka, Hisako Sato, Kazuki Sasaki, Yuriko Minegishi, Yoshio Kodera, Irene Fernandez‐Cuesta, Boris Krichel, Norie Araki, Andreas Tholey ISSN: 1615-9853,

Further information

Tobias Waldmann, Philipp T. Kaulich, Alexander Stolz, Andreas Tholey, Christian Neusüß ISSN: 0003-2700,

Further information

Jasmin Schairer, Jennifer Römer, Dietmar Lang, Christian Neusüß ISSN: 1618-2642,

Further information

Annika A.M. van der Zon, Alisa Höchsmann, Tijmen S. Bos, Christian Neusüß, Govert W. Somsen, Kevin Jooß, Rob Haselberg, Andrea F.G. Gargano ISSN: 0003-2670,

Further information

Alisa Höchsmann, Laura Dhellemmes, Laurent Leclercq, Hervé Cottet, Christian Neusüß ISSN: 0173-0835,

Further information

Elahe Naghdi, Marika Ejby Reinau, Thomas Nylandsted Krogh, Christian Neusüß ISSN: 0003-2700,

Further information

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Prof. Dr. Christian Neusüß

Research

Research Projects

Equipment

Resumé

Dean of Studies, Studies Dean "Analytical and Bioanalytical Chemistry"

Professors / Professor of the academic staff for General and Analytical Chemistry

Research assistant/associate/fellow / application chemist at Bruker Daltonik GmbH

Research assistant/associate/fellow at the Department, Institute for Tropospheric Research

Studied chemistry in Heidelberg (German university degree 1996) and Bergen (Norway)

Publications

Meeting Report

Selective Comprehensive Online NanoLCxCZE-MS Platform for Top-Down Proteoform Analysis

CE-MS/MS and CE-timsTOF to separate and characterize intramolecular disulfide bridges of monoclonal antibody subunits and their application for the assessment of subunit reduction protocols

Characterization of monoclonal antibody charge variants under near-native separation conditions using nanoflow sheath liquid capillary electrophoresis-mass spectrometry

Charge variant analysis of monoclonal antibodies by CZE‐MS using a successive multiple ionic‐polymer layer coating based on diethylaminoethyl‐dextran

Chemical Mobilization-Based Capillary Isoelectric Focusing–Mass Spectrometry Using the nanoCEasy Interface for Pharmaceutical Protein Analysis